A deadly viral outbreak occurs in the Hive, an underground genetic research facility run by the Umbrella Corporation. In response, the Red Queen - a vast supercomputer that controls and monitors the Hive - seals the entire facility. A rescue team has to enter the Hive and isolate the virus. But they soon discover that the staffs in the Hive are now the ravenous, zombie-like Undead. The team is attacked and some teammates are turned into ravenous. Are they doomed to turn Undead? Who, if anyone, will escape the evil Hive alive?