Wolvesbayne uncovers the supernatural world wherein vampires and werewolves coexist. Centuries ago, Lilith (Yancy Butler), the first vampire was banished but she manages to return and starts a civil war within the vampire clan. This war of beasts threatens to tear the worlds of vampire, werewolves and humans apart. Russell Bayne (Jeremy London), after bitten by a werewolf, finds himself in the middle of this supernatural war. Bayne must learn to control his new powers and gather the human hunters, werewolves and other vampire clan to assemble amulets to put Lilith back to her imprisonment before she destroys the human world.